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Jim & Genia Graves

Surprise, Arizona 85041

623-810-9765

graves@graveslabradors.com

 

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CNM

CNM - Centronuclear Myopathy


Disease Description
Centronuclear Myopathy (CNM), formerly called Labrador Muscular Myopathy or Hereditary Myopathy of the Labrador Retriever (HMLR) as well as many other names, segregates in Labrador Retrievers. The disease was first observed in the 1970's. By the 1990's, the incidence had increased significantly. This increase is globally due to famous successful Labradors who are carriers being used extensively for breeding.
At this time, there is little on the disease in handbooks and clinical manuals typically used by veterinary clinics. This is due to the documents being published perhaps every five years, and because this myopathy is a breed-specific disease.   There are extensive efforts to notify the thousands of veterinary clinics that there is now a simple DNA test, but it is a slow process.
CNM is a hereditary disease where the muscles of the Labrador do not develop properly.   Affected pups are obvious by the time they are between three and six months of age.  The pup will begin to stumble and fall when trying to walk. There are difficulties in swallowing since the muscles in the esophagus are often affected.  There is no cure for the disease.  See http://www.youtube.com/watch?v=NceEeiuNJCQ&feature=fvw or http://www.youtube.com/watch?v=RY1DWQqoac0 for a picture of an affected pup.
CNM is a simple autosomal recessive.  Please go to www.labradorcnm.com and look at the Genetics link in the left menu for charts on breeding.   Consider the charts before planning a breeding. (See my chart below)


Diagnosing CNM Affected, Carrier, and Clean Labrador Retrievers.
The CNM DNA test, available at www.labradorcnm.com, is highly reliable in identifying the disease. It can determine affected, carriers, and clean CNM Labradors.    It is inexpensive and involves a non-painful collection of cells from the inside of the canine’s cheek.   The owner can easily do the test themselves, or can choose to go to a veterinarian.  The CNM Project provides kits and e-forms with very specific easy directions. 
The only other way to determine if a parent in a Labrador litter is a known carrier would be if an affected pup had been produced.  At one time biopsies were also used, but these have been abandoned as a method since they do not identify carriers and are expensive and invasive.
CNM clear Labradors are placed on an International Registry – White List, available only at www.labradorcnm.com . The list is continuously updated with names of clear CNM Labradors.  Check there to see if the parents of a pup you are considering are found on the list.  If not, discuss with your breeder.
For questions and further information on CNM, write to info@labradorcnm.com or browse the CNM web site at www.labradorcnm.com 

CNM

Pricing summary - 2010
CNM Genetic Test

Item

USA and Canada
In USA Dollars

Europe and
Other Countries

Test Analysis
And Kit

$55
Including
Kit

45

Including
Kit

Change from
no--name to name

Free

Free

Frozen Semen Analysis Veterinary
Directions will be sent
By contacting
info@labradorcnm.com

$55
including
Kit

45

including
Kit

Litters

$50
Per pup including Kits $300 for 6 or more
Pups Contact
litter@labradorcnm.com
For details

40 € per pup
Including Kits 240€
For 6 or more pups
Contact
litter@labradorcnm.com
For details

Kennels (more than 8 dogs)
And Clinics

Please contact
info@labradorcnm.com
for details and discounts

Please contact
info@labradorcnm.com
for details and discounts

Visa and Master Cards may be preferentially used.
Do not include US or Canadian Postal Money Orders
as they are not negotiable in France.

 

Breeding Chart I designed

1 Stands for +/+ (clear) 1 1 Stands for +/CNM (carrier)11Stands for CNM/CNM (affected)

 

Breeding two clear dogs

 

+/+

1Sire

+/+

11Dam

1
1
1
1

 

Breeding a clear dog to a carrier dog

 

+/+

1Sire

+/CNM

1Dam

1
1
1
1

 

Breeding two carrier dogs

 

+/CNM

1Sire

+/CNM

1Dam

1
1
1
1

 

Breeding a clear dog to an affected dog

 

+/+

1Sire

CNM/CNM

1Dam

1
1
1
1

 

Breeding a carrier dog to an affected dog

 

+/CNM

1Sire

CNM/CNM

1Dam

1
1
1
1

 

Breeding two affected dogs

 

CNM/CNM

1Sire

CNM/CNM

1Dam

1
1
1
1